The IRB's role and function are delineated by Dutch national rules and regulations, as well as ACTA’s own internal policies and procedures. Protection of the rights and welfare of human research subjects constitutes the IRB's central purpose. For Medical Ethical approval, if legally required, the University of Amsterdam or VU University Medical Ethical Committee need to be consulted.
The IRB board members represent the ACTA scientific and organisational community. If necessary, ad hoc external experts may be asked to review/audit a protocol if the at hand content needs this. The IRB gives individualised attention to the numerous research projects it receives each year. Also, the IRB advises on non-research activities that may affect ACTA’s reputation with regard to education, research, or care.