An easy to use stainless steel biofilm-model that fits on standard 24-well plates.
- Grow up to 24 individual biofilms
- Biofilm growth requires active attachment – not aggregation
- Use different substrata – “anything that can be fixed”
- Use different types of clamps / plugs
- Have proper control over exposure when testing treatments, no wash-out periods
- Test different growth media in a single experiment
- Remove samples without interfering with the remaining samples
- Model can be re-used – no contact between lid and biofilm
- Model can be autoclaved after assembly
References
- Exterkate, R. A., et al. (2010). "Different response to amine fluoride by Streptococcus mutans and polymicrobial biofilms in a novel high-throughput active attachment model." Caries Res 44(4): 372-379.
- Fernandez Y Mostajo M et al. (2017) Effect of mouthwashes on the composition and metabolic activity of oral biofilms grown in vitro. Clin Oral Investig. 21(4):1221–1230.
More information
Contact Rob Exterkate through R.Exterkate@acta.nl.